PO-02-015 THE IMPACT OF GENDER AND LV SIZE ON CARDIAC RESYNCHRONIZATION THERAPY RESPONSE

Multiple studies have reported that female gender is predictive of positive response to cardiac resynchronization therapy (CRT). However, the mechanisms underlying this association remain unclear. We aimed examine between and echocardiographic CRT (reduction in LV end systolic volume (LVESV) >15% at 6 months), patients recruited MORE-CRT MPP study. a prospective, randomized, multicenter All initially receive conventional biventricular (BiV) for months. At stage, non-responders are randomized either continued BiV pacing, or MultiPoint pacing. This post-hoc analysis examined predictors initial months pacing only. performed univariable models using baseline variables. Multivariable were conducted stepwise model selections (n = 2,866). The criteria variables entering staying into was α=0.25 α=0.05, respectively. Age forced model. Of 3739 analysis, 28% female. size females significantly smaller compared males (175.8±60.3ml vs. 228.3±76.9ml, p<0.0001). Males had broader QRSd than (157.7±26.1ms 152.3±22.1ms, logistic regression showed that: no history AF, non-ischemic aetiology, left bundle branch block (LBBB), heart (↓LVEDV), wide QRSd, renal disease, significant independent (see table). In separate model, QRSd/LVEDV ratio predictor but not multivariable with included (OR 1.21 95% CI 0.89-1.63, p=0.22). Female superior response. from including: LBBB QRSd. QRSd/LVEDV, measuring dyssynchrony relative size, independently when analysis. suggests superiority may be related higher degree (higher ratio). benefit lower cut-off considering their suitability CRT, based on thus given